Distribution of β-endorphin-related peptides in rat pituitary and brain
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چکیده
منابع مشابه
Regional distribution of dynorphin and neo-endorphin peptides in rat brain, spinal cord, and pituitary.
Five products of the dynorphin gene--alpha-neo-endorphin, beta-neo-endorphin, dynorphin A, dynorphin A-(1-8), and dynorphin B--were measured in various regions of rat brain and in rat spinal cord and pituitary. Specific antisera were used, supplemented by gel permeation analysis and high performance liquid chromatography, confirming the presence of dynorphin-32, dynorphin A, and dynorphin B in ...
متن کاملIdentification of endorphin acetyltransferase in rat brain and pituitary gland.
An enzyme which N-acetylates beta-endorphin has been identified and characterized in the rat brain and pituitary gland. The beta-endorphin acetyltransferase activity was localized almost exclusively in the intermediate lobe of the pituitary gland. beta-endorphin acetyltransferase activity was also present in the hypothalamus, a brain region which synthesizes beta-endorphin, but not the cerebell...
متن کاملPurification of calcitonin-like peptides from rat brain and pituitary.
Accumulating evidence supports the existence of nonthyroidal calcitonin (CT)-like peptides, more similar to fish CTs, which may act as endogenous regulators of CT receptors in brain and other tissues. In this study, we have carried out large-scale extractions from Sprague-Dawley rat brain diencephalon and pituitary, and purified a novel, biologically active, CT-like peptide from pituitary. Moni...
متن کاملCharacterization of pro-ACTH/endorphin-derived peptides in rat hypothalamus.
The proteolytic processing pattern of pro-ACTH/endorphin in rat hypothalamus is similar to the pattern in the pars intermedia; peptides the size of beta-endorphin, gamma-lipotropin (gamma-LPH), corticotropin-like intermediate lobe peptide (CLIP), alpha-melanotropin (gamma-MSH), joining peptide, and glycosylated gamma 3-MSH all represent predominant end products. Equimolar amounts of beta-endorp...
متن کاملBIOSYNTHESIS AND RELEASE OF P-ENDORPHIN-, N-ACETYL p- ENDORPHIN-, /3-ENDORPHIN-(l-27)-, AND N-ACETYL P-ENDORPHIN- (l-27)-LIKE PEPTIDES BY RAT PITUITARY NEUROINTERMEDIATE LOBE: P-ENDORPHIN IS NOT FURTHER PROCESSED BY ANTERIOR LOBE’
Continuous labeling and pulse-chase techniques were employed to study the synthesis and secretion of multiple forms of immunoreactive ,f?-endorphin by cultured dispersed rat anterior lobe cells and intact neurointermediate pituitary lobe. Cell and medium extract immunoreactive pendorphin (specific immunoprecipitation and radioimmunoassay) exhibiting a K,, similar to authentic ,&endorphin upon g...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1982
ISSN: 0264-6021
DOI: 10.1042/bj2020561